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Hi Nina, I just noticed that you are taking CR and Eldepryl. Both of those caused excessive diskinesia in Nancy around year 14 of her 24 years with PD. You may want to try taking less CR and more regular sinemet. That change helped Nancy a great deal prior to her pallidotomies in year 20. Also prior to her palidotomies Eldepryl had to be discontinued because she literally started bouncing off the walls. I suggest you consider titrating from CR to regular first. If that doesn't work then back off the Eldepryl. As you know Nancy still has very little dyskinesia today regardless of how much sinement she takes. Strangely, Tasmar even without Sinemet, could resurrect her dyskinesia shortly after taking the pill, so she does not take Tasmar. I do believe the stress of your move could also play a role in the dyskinesia so you may try the changes and if they "calm you down" then consider returning to your old regimen. hope this helps, Bob Martone -----Original Message----- From: Parkinson's Information Exchange [mailto:[log in to unmask]] On Behalf Of Lanny D. Weddel Sent: Sunday, September 19, 1999 5:42 PM To: [log in to unmask] Subject: Re: Dyskinesias The attached seems to touch on "stress induced exacerbation of PD symptoms". What's the chance that someone could point me in the direction of a medical journal or some other source of peer reviewed articles. I am preparing for a probable appeal of LTD benefits and needed to shore up the legal support that stress does impact PWPs physically. ~~~~~~~~~~~~~~ Lanny D. Weddel [log in to unmask] ~~~~~~~~~~~~~~ ----- Original Message ----- From: Nina P. Brown <[log in to unmask]> To: <[log in to unmask]> Sent: Sunday, September 19, 1999 3:53 PM Subject: Re: Dyskinesias > Janet, thanks for asking and any help you can offer. > > Your question as to anything changed? > We moved into a new home in the past few months, > but until now I didn't consider that it might be > stress induced. Amazing how we can be oblivious > to things sometime, although I'm not sure that is > actually the reason...but could be, I guess. > Sorry, I should have included the med schedule. > It follows: > > (Usually around 9:00 am) Sometimes it takes till the > next dose to get "on", But if I take more, I end > up with dyskinesia that is worse than being "off" > > ½ 25/100 Sinemet > 5 mg. Selegline > 100 mg. Symmetrel > 1 mg. Mirapex > > 3 HOURS LATER: about 12:00 > 1 25/100 Sinemet CR > 1/2 mg. Mirapex > > 4 HOURS LATER 4:00 pm > 1 25/100 Sinemet CR > 1/2 mg. Mirapex > > Sometimes I take another 4 HOURS LATER 8 PM > 1/2 25/100 Sinemet > > Thanks again, > nina > > > > janet paterson wrote: > > > hi all > > > > At 01:34 1999/09/19 -0500, nina wrote: > > >Help! > > >I've made a few comments every now and then, but now I have a question. > > >My dyskinesia has gotten appreciably worse the past few months. I've > > >cut back on meds, but that just tends to give me longer "offs".... > > > > tell us your med schedule and dosages > > > > has anything else changed in the past few months? > > > > janet > > > > janet paterson > > 52 now / 41 dx / 37 onset > > 613 256 8340 po box 171 almonte ontario canada K0A 1A0 > > a new voice: <http://www.geocities.com/SoHo/Village/6263/> > > <[log in to unmask]> >