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marty well said murph On Wed, 22 Sep 1999 03:18:01 EDT Marty Polonsky <[log in to unmask]> writes: > Erviin, > You may have already gotten sufficient response to your questions > but I > though I'd put in my 2 cents worth and maybe it will be of some > help. I have > been stable on 3mg mirapex per day for well over a year and I > participated in > a study of mirapex (pramapexol) before it was approved, and I've had > no > problems with it at any time--but, as you well know, everyone reacts > differently to meds, and my body tends to resist the effects, both > positive, > main effects and negative side effects of most drugs. Consequently, > I end up > needing large doses of most meds for them to be effective. > Consistent with > this, I took very high levels of sinemet before my bilateral > pallidotomies > and I also developed a raging case of dykinesia. After that, I > found that > almost any drug--including an increase in my mirapex-- made my > dyskinesia > worse. My understanding, after talking with several neuros re my > experience > is that sinemet is the primary offender in causing dyskinesia but > that > virtually any of the current PD drugs, in combination with sinemet, > can > cause, or worsen dyskinesia. And, one neuro told me that everyone > who takes > sinemet over a period of time can expect to become dyskinesic. For > this > reason, yes, it is a good idea to avoid or postpone taking sinemet, > if you > can. Typically, the only time that's possible is in PD's earliest > stage, > which it sounds like you may still be in. In the meantime, until > something > better comes along sinemet continues to be the "gold standard"--to > borrow a > phrase--of meds in PD treatment,.and most PD people end up taking > it. > I hope that helped a little, and good luck to you,.as you begin > your > journey. > > Marty Polonsky