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I have some concerns about my mom's mental state and thought I'd solicit some insights from the group. Let me start by saying that my mother recently increased her Sinemet dose from 25/100 3x/day to 25/100 4x/day. (She also takes Requip, Artane, and Zoloft.) Also, I don't know whether the changes I am about to describe started around the time of the change in dosage -- I will try to find this out, but I don't know whether it's possible. Every once in awhile, my mom will say things "Is so-and-so still sleeping" when, in fact, there is no "so-and-so" at her house. She said she spoke to someone recently and commented that he sounded bad (the person in question died a few months ago). These sorts of comments. What I'm wondering is (1) is this something to bring to her doctor's attention immediately? (2) Has anyone noticed this sort of thing being a prelude to something much worse? Any comments would be helpful and, again, thanks. Debbie White [log in to unmask]