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Erviin, You may have already gotten sufficient response to your questions but I though I'd put in my 2 cents worth and maybe it will be of some help. I have been stable on 3mg mirapex per day for well over a year and I participated in a study of mirapex (pramapexol) before it was approved, and I've had no problems with it at any time--but, as you well know, everyone reacts differently to meds, and my body tends to resist the effects, both positive, main effects and negative side effects of most drugs. Consequently, I end up needing large doses of most meds for them to be effective. Consistent with this, I took very high levels of sinemet before my bilateral pallidotomies and I also developed a raging case of dykinesia. After that, I found that almost any drug--including an increase in my mirapex-- made my dyskinesia worse. My understanding, after talking with several neuros re my experience is that sinemet is the primary offender in causing dyskinesia but that virtually any of the current PD drugs, in combination with sinemet, can cause, or worsen dyskinesia. And, one neuro told me that everyone who takes sinemet over a period of time can expect to become dyskinesic. For this reason, yes, it is a good idea to avoid or postpone taking sinemet, if you can. Typically, the only time that's possible is in PD's earliest stage, which it sounds like you may still be in. In the meantime, until something better comes along sinemet continues to be the "gold standard"--to borrow a phrase--of meds in PD treatment,.and most PD people end up taking it. I hope that helped a little, and good luck to you,.as you begin your journey. Marty Polonsky