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Thanks for the input Marty. I wish Mirapex would have done well by me because I disliked using Sinemet this early. But I guess I will just have to go for the gold. In four weeks of titrating up I haven't noticed much difference. [log in to unmask] ----- Original Message ----- From: Marty Polonsky <[log in to unmask]> To: <[log in to unmask]> Sent: Wednesday, September 22, 1999 12:18 AM Subject: Re: Dyskinesias > Erviin, > You may have already gotten sufficient response to your questions but I > though I'd put in my 2 cents worth and maybe it will be of some help. I have > been stable on 3mg mirapex per day for well over a year and I participated in > a study of mirapex (pramapexol) before it was approved, and I've had no > problems with it at any time--but, as you well know, everyone reacts > differently to meds, and my body tends to resist the effects, both positive, > main effects and negative side effects of most drugs. Consequently, I end up > needing large doses of most meds for them to be effective. Consistent with > this, I took very high levels of sinemet before my bilateral pallidotomies > and I also developed a raging case of dykinesia. After that, I found that > almost any drug--including an increase in my mirapex-- made my dyskinesia > worse. My understanding, after talking with several neuros re my experience > is that sinemet is the primary offender in causing dyskinesia but that > virtually any of the current PD drugs, in combination with sinemet, can > cause, or worsen dyskinesia. And, one neuro told me that everyone who takes > sinemet over a period of time can expect to become dyskinesic. For this > reason, yes, it is a good idea to avoid or postpone taking sinemet, if you > can. Typically, the only time that's possible is in PD's earliest stage, > which it sounds like you may still be in. In the meantime, until something > better comes along sinemet continues to be the "gold standard"--to borrow a > phrase--of meds in PD treatment,.and most PD people end up taking it. > I hope that helped a little, and good luck to you,.as you begin your > journey. > > Marty Polonsky