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I have taken Prediisone foa 15 years. It does make one feel 'good" and keeps away the mustache blues. Maybe it'll even help the PD, it''ll have to wait another five years to see some benefits or I shouldn't haves. I take progesterone too, plus Sinement CR, Permax, and zoloft. I rattle when I move, from all those pills This is a dream and I'm going to wake up soon, right? What a nightmare this PD is!. It sure doesn't help growing old., which is something else I don't like. Patricia 63/5 years