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There is a probable causal relationship between p210 (SHIP2) protein tyrosine kinase activity and the manifestation of chronic myelogenous leukemia. SHIP2 is a unique SH2-domain containing protein closely related to phosphatidylinositol polyphosphate 5-phosphatase. SHIP2 like SHIP1 are linked to downstream signaling events after activation of hematopoietic growth factor receptors. PI3 or phosphatidylinositol 3 and PI2 are implicated in growth-factor mediated signaling. - SHIP2 - Pub Med Breakpoint cluster region - Pub Med - Chronic myelogenous leukemia is fundamentally a genetic disorder, specifically a somatic cell genetic disorder which has environmental causes. Retinoic Acid Receptor, Alpha, RARA - Acute promyelocytic leukemia, the breakpoints in 10 APL cases were shown to cluster in the 12-kb region on chromosome 17. See Wells 1997 and NUMA1 for discussion of a RAR/NUMA1 fusion protein associated with APL. Tretinoin - is a retinoic acid - 3,7-dimethyl-9-(2,6,6-trimethyl-1-cyclohexen-1-yl)-2,4,6,8-nonatetraenoic acid. It controls the differentiation and proliferation of many types of cells including dopamine cells. (This is why I think dimethylamine and trimethylamine might have something to do with Parkinsons.) Identification of break points in PMP22 gene in a new Trembler (Tr-Ncnp) mouse - Pub Med Characterization of RAC3, a novel member of the Rho family - Pub Med. Rac3 is an active GTPase, and this activity is regulated by Bcr or breakpoint clusters. RAS-related C3 Botulinum Toxin Substrate 3, RAC3 - Pub Med. (BOTOX) Effects SNAP25 chromaffin cells. [log in to unmask]