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D2 receptors are not associated with adenylate cyclase in Parkinsons Disease, rather they act through phosphoinositide hydrolysis (McGreer and McGreer 1993) Wortmannin and its derivatives are antifungal antibiotics isolated from the culture filtrates of several Penicillium and Myrothecium species. Both metabolites are potent antiinflammatory agents. Wortmannin has been shown to inhibit phosphatidylinositol 3-kinase as well as the phosphorylation of ethanolamine and choline. It reacts with p110alpha, the catalytic subnet of PI-3 kinase. SHIP2 - Pub Med - We describe here identification of a 155 kD tyrosine phosphorylated protein associated with src homologous and collagen gene from p210(bcr/abl) expressing hematopoietic cells as SHIP2, a reported, unique SH2-domain containing protein closely related to phosphatidylinositol polyphosphate 5-phosphatase SHIP. Amantadine is an anti-Parkinsonian, antiviral agent, especially against the influenza virus. Amanita is a genus of fungi of the family agaricaceae; most species are poisonous. Immunodominant peptide NPP147-155 of influenza virus nucleoprotein (Spontaneous mutation at position 114 affects T-cell responses to influenza infection - Pub Med. Transglutaminase inhibition imidazolium: mechanism of factor XIIIa inactivation - Pub Med (N-Methyl-Methylglycoxal-imidazolium) Human factor VIII - Pub Med Human factor VIIIdelta - 155kd Interleuken-1 beta binds to a single class of high affinity receptors with a kd of 155. It is shown that IL-1 is able to induce MHC II antigen expression. - IL-beta - Pub Med. Parkinsons has elevated gamma T-cells. MHC II antigens are involved with lipids. 3-Hazidopine - Pub Med - We have succeeded in labeling proteins from chloroquine resistant human falciparum malaria parisites. Relatively little or no labeling of the 155-170 kD protein is seen in the chloroquine sensitive strain of 3H-azidopine. Further competition can be seen with reserpine. (Reserpine causes Parkinsons Disease symptoms.) The heliothis virescens 170 kD aminopeptidase functions as a receptor by mediating specific Bacillus Thuringiensis cRY1a delta-endotoxin binding and pore formation - Pub Med. Purified aminopeptidase N with molecular sizes of 110, 140, and 170 kD were eluted from CrylAc toxin. The aminopeptidase has a cross-reacting determinant typical of a cleaved glycosyl-phosphatidylinositol anchor. The toxin is used to kill mosquitoes. [log in to unmask]