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Sorry for asking but do receptors "release"? Maryse Sharon & Jim LeBlanc a écrit: > (Parkinsons Disease by Christopher Johnson) > There are D1 receptors on striatal neurons which release a combination of > the neurotransmitters GABA and substance P. When the D2 receptors bind > dopamine these neurons emit tonic inhibitory output to the external globus > palidus, which itself has tonic inhibitory projections to the subthalamic > nucleus. > Requip binds to D1 and D3 dopamine receptors. > Mirapex prefers the D3 receptor. > D3 receptors are associated with opiate dependence (Pub Med - Homozygosity > of the dopamine D3 receptor) > Elevated levels of substance P have been described in fibromyalgia which is > a syndrome of widespread pain and sleep disturbance. > (Relationship of substance P and tryptophan - Pub Med) (Substance P is > related to pain) > GABA - B inhibits substance P. (Gama-aminobutyric acid B - Pub Med) > Gamma-hydroxybutyric acid is used to treat Narcolepsy. (Pub Med) > Analysis of the monoamine oxidase genes and the Norrie disease gene locus > in Narcolepsy. > Methamphetamines increase substance P and cause dystonia and are used to > treat Narcolepsy. > Isoniazid is well known to increase concentrations of gamma-aminobutyric > acid (GABA), and to relieve dystonia. > > SO let me see if I get this right. > If you decrease Gaba too much and increase substance P, you will get > dystonia and be wide awake. > If you increase Gaba and inhibit substance P too much you will get > Narcolepsy but feel great. > Parkinsons has too much dopamine not converted to dopa. The dopamine > inhibits GABA and you get dystonia and can't sleep . > Parkinsons has not enough monoamine oxidase inhibitors, and when you don't > have any like Norrie disease you get Narcolepsy. > > This is just my opinion, but Mirapex and Requip increase (R)Salsolinol. > That is why they help. And it looks like they increase Gaba. > You naturally make N-Methyl in your intestines. Eventually you get N-Methyl > (R) Salsolinol which causes Parkinsons. > (Analgesic effects of 3-carboxysalsolinol alone and in combination with > morphine ) Suggests an interaction with central opiate receptors. Central > opiate receptors are D3. Mirapex and Requip boost D3. Why don't > parkinsonians just take GABA that you can buy over the counter for sleep. I > would think it would help the dystonia without all the side effects. Then > again I don't know if it is GABA-A or GABA-B. All I know is that it does > work for sleep. > > Also, Mirapex which has a benzathiazol concerns me since the > 1-benzy-tetrahydroisoquinolines interact with the alpha-adrenergic > chromaffin cells. Botox neurotoxin for dystonia effects SNAP-25 of the > chromaffin cells. It reduces epinephrine and norepinephrine. > > Elevated norepinephrine has been shown to cause dystonia.(Dyskinesias > possibly induced by norpseuto4ephedrine)- Pub Med. > Ephedrine stimulates the hormone norepinephrine. > > Just putting things together. Thanks for listening. > > [log in to unmask]