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Ervin..... Many Parkies (including myself) are susceptible to itchy-type skin irritations -seborrhea <> working over-time, I gather. Before you give up Sinemet, you might try taking Benedryl, an over the counter anti-histamine. That made the itching tolerant for me and I still take Sinemet. Barb Mallut [log in to unmask] -----Original Message----- From: ERVIN J MCCARTHY <[log in to unmask]> To: [log in to unmask] <[log in to unmask]> Date: Saturday, October 02, 1999 10:34 AM Subject: Sinemet Has any one had a body itching rash as a result of Sinemet? I have been told to back off the drug and eventually discontinue it. If this is the gold standard for Parkinson's where do we go from here? [log in to unmask]