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Dear Jo, levodopa ethylester (LDEE) has been written about (experimentally at least) for several years and I think is/might be available in Israel?? Wonder why it is taking so long to get on to the market? Any clues as to why? Joy Graham ......................... >Carole Hercun wrote: >> Hi Joe: Interested in these alternative delivery >> systems for levodopa. Can you post some references? > >I learned about the pump from our late and sorely missed listmember >Alan Bonander, who wore one to cope with the problem of dosage. As >PD advances, the 'therapeutic window' between too much (dyskinesia) >and too little (dystonia, rigidity) seems to shrink, and the >continuous infusion pump offered Alan a temporary respite. >The citation about injectable levodopa ethylester (CSR APR 96) is below. >As to the skin patch, I can't find the citation, perhaps I just heard >it at some local seminar, or (egad! cognitive decline so soon!) I could >be mistaken. > >Djalderti R, Melamed E; Ann Neur 1996;39:400-404: >A hindrance to levodopa absorption is its poor solubility. A new >precursor, levodopa ethylester (LDEE) injected subcutaneous or >intra-muscularly is well tolerated, reduces off-on fluctuations, and >avoids side effects of oral administration. > >Cheers, >Joe >-- >J. R. Bruman (818) 789-3694 >3527 Cody Road >Sherman Oaks, CA 91403-5013