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Bob, Joy and All, Oops, I for to add the directions earlier. NADA is supposed to be a dopamine stimulant and to prohibit dopamine auto-oxidation. Recommendations are 3-4 5mg tablets on an empty stomach (20-30 minutes before eating) per day, depending on severity of symptoms, per Jorg (Georg-George) Birkmayer, in an interview appearing in Whole Foods April 1997 page 80; the entire article appears on pages 72-80. In March 1996 Georgetown University was beginning a study on NADA for chronic fatigue syndrome; I've not heard of any results. I assume these to be double blind studies. Another institute was going to do double blind studies on NADA and athletes/triathletes performance. Please let us know what your results are.