Wendy, There is no absolute maximum amount of Sinemet. The effective maximum will vary from patient to patient. There is one man from our local support group who has been cut back to 19 Sinemet tablets per day [plus agonists, eldepryl, & amantadine]. I think your mum would do better with a little more - but not a lot more. Doses 4 hours apart might do her a better job. You did not say what the dosage every 6 hours was. Will Johnnston A.P.D.A. DelMarVA Chapter Pres. 4049 Oakland School Road Salisbury MD 21804 USA 410-543-0110 ---------- From: w y <[log in to unmask]> To: [log in to unmask] Subject: Sinemet Dosage Date: Tuesday, October 12, 1999 7:32 AM Hi all, Can anyone tell me what is the maximum mg of Sinemet can be taken up to daily. This is because my mum has been taking Sinemet but experienced dyskinesia and her doctor has changed to Madopar which is also another kind of levodopa but the dosage seems not enough to cover the six hourly break. And it seems quite hard for her to tolerate such great pain. Please advise. -WENDY- ===== __________________________________________________ Do You Yahoo!? Bid and sell for free at http://auctions.yahoo.com