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Michel, thanks!! I'm going to take this post to a pharmacist, and see if it sparks a better answer. Best, Kathrynne Michel Margosis wrote: > > Kathrynne Holden, MS,RD wrote: > > > Brian, some U.S. cola drinks are fairly acidic, despite the sugar -- > > vinegar has a pH of 3.1 - 3.2, while the average cola has a pH of 2.4, > > 7-UP 3.0, and club soda 3.7. > > > > I've heard, but not been able to substantiate, that carbonated beverages > > hasten the action of Sinemet; no pharmacist I've talked to can explain > > or back that up, however. > > If I remember some old chemistry, there is an optimum pH where the two > functional groups, -COOH (acid) and -NH2 (amine) are in equilibrium, perhaps a > zwitter ion. Thus if you alter the acidity one way or the other, you will > favor one group, then the other. This will also affect the solubility, hence > the partitioning of the drug. > I hope this was confusing enough to put you to sleep. > Note that this is far less funny than my daily jokes. > Michel -- Kathrynne Holden, MS, RD Medical nutrition therapy Author: "Eat well, stay well with Parkinson's disease" "Parkinson's disease: assessing and managing unique nutrition needs" http://www.nutritionucanlivewith.com/