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process analysis of getting levodopa from mouth to brain (rudimentary) the taking of med with water gets it to the stomach if the stomach is not full (we are at least one hour from last meal) but is actually empty, the dissolving will take more time than if there is some nutrient which induces the digestive juices. this latter is supplied by a peppermint, orange wedges, ginger, carbonated sugar water, or a graham cracker, a plum, et cetera the levodopa must be carried along with some food/nutrient into the bloodstream. with nothing but water, this will be slower then, the traveling around the body in the blood depends upon blood flowrate and volume i was surprised to read in the Mirapex package insert that it apparently speeds up the absorption of levodopa. from peaking at over an hour to peaking at 30 minutes. my personal experience has not been noticeably different since i started using mirapex. the time as always been about 20 to 30 minutes. a little better if i crumble the tablet of levodopa with my teeth before swallowing it. hope this helps -- Ron Vetter 1936, '84 PD dz mailto:[log in to unmask] http://www.ridgecrest.ca.us/~rfvetter