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Hi. This is my first communication as a new member of this list or any internet exchange. I am 47 years old and was diagnosed with Parkinson's about one year ago, after two years of uncertain diagnoses of multiple sclerosis and primary lateral sclerosis. I have no tremor, and the symptoms of Parkinson's--muscle rigidity, balance problems, slow movement, etc.--currently affect the left side of my body more than the right. I presently use Sinemet 25/100 five times daily in combination (within the last few months) with 1 gram Mirapex three times daily. I'm not yet sure what effect, if any, the Mirapex provides, although the effect of the Sinemet is certainly dramatic. Unfortunately, I have developed "variable response" syndrome with respect to the Sinemet. My current physician, a neurologist whose subspecialty is Parkinson's) tells me that it would have been preferable not to have begun my treatment with Sinemet because of the possibility of developing this very syndrome--hence the experiment with Mirapex. (The Sinemet was originally prescribed by my current doctor's colleague, a well-respected neurologist whose subspecialty is multiple sclerosis.) I am a lawyer whose focus is civil litigation. In order to function during the day, I find that I need to use the Sinemet at no less than 3.5 hour intervals, which means significantly less function at night. I also find that I need to rest for about 30 minutes before each dose of Sinemet, which can be problematic. All of this makes professional life difficult. It is also a nuisance at home, where evenings are usually devoted to activities with my husband. Any thoughts for a newcomer about managing what must be a familiar scenario to most of you? Sorry for the long initial message and thanks in advance for your time. Rhonda