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Rhonda, An interesting note. 18 months ago I worked my way down from 7 50/200 ( I believe it was -- prescribed by a neurologist at Boston's Beth Israel, whose care then left, joining the Neurological Referral Center at B Medical Ctr.) sinemets/day to my current dosage (same as yours), plus the addition of: 4 mirapex/day; 2 eldypryl (seligiline)/day; and 2 Tasmar daily. I believe that the other three grease the skids for and make more effective the sinemet. Best regards, John Bachman 57, 4, 6