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That is a good caveat to note. A difference in bioavailability whether increased or decreased may occur between "lots" or between generics. With all generics one should especially watch if the manufacturer changes and be aware of the possibility of change in efficacy. It is unlikely but it can happen. Therefore it is best that one insist on the same manufacturer or watch to see whether a change in symptoms occurs with a change in generics. This does not mean I am against generics. I support their use. Just do it with some caution. Charlie ----- Original Message ----- From: Earnie & Barbara Knight <[log in to unmask]> To: <[log in to unmask]> Sent: Saturday, October 16, 1999 2:26 PM Subject: Re: Generic drugs > At 02:21 PM 10/15/99 -0700, you wrote: > >Joe Thome wrote: > > > >> Does anyone have any recomendations for or against the use of generic > >> drugs as opposed to brand name drugs? > >> > > I used to think the generics were as good as the real thing. So when my > doctor prescribed Eldepryl, I accepted the generic Selegiline HCL. I took > this for two months along with a generic for Sinemet, and it seemed to > really help. These two months the Selegiline was from the same > manufacturer. When I had the prescription refilled, I received Selegiline > from a different manufacturer. I didn't pay much attention to this, > thinking a generic is a generic. But after taking the new pills for a > couple of days, they didn't seem to be having the same effect as the other > ones. I thought at first it was just my imagination, and took them for a > few more days. I decided then something was wrong. > > I did a search on the internet for Eldepryl and Segegiline. The only thing > that seemed to be really different between the real thing and the two > generics were the filters - and the filters were also different between the > two generics. > > At the risk of sounding foolish, I took the bottle back to the pharmacy, > and explained I didn't think it was working as well as the first one. I > told the pharmacist I didn't mind getting the generic, but wanted it from > the same manufacturer. I didn't want to be switching manufacturers every > time I got a refill. The pharmacist was really nice about it, and placed an > order for pills from the first manufacturer. He also noted in my records > what had happened. And he didn't charge me for the replacement. > > This has changed my thinking on generics. After reading Janet Patterson's > post about her experience with generic Sinemet, I checked my prescription > and it was from Endo. Guess I'm not so sure I will accept a generic at face > value next time. (Sigh). > > Barbara 61/61/51?