Thanks for that clarification Michel. I guess the bioavailability test is done by us titrating our symptoms vs. the drug :-( Charlie ----- Original Message ----- From: Michel Margosis <[log in to unmask]> To: <[log in to unmask]> Sent: Saturday, October 16, 1999 11:42 PM Subject: Re: Generic drugs > Charles T. Meyer, M.D. wrote: > > > That is a good caveat to note. A difference in bioavailability whether > > increased or decreased may occur between "lots" or between generics. With > > all generics one should especially watch if the manufacturer changes and be > > aware of the possibility of change in efficacy. It is unlikely but it > > can happen. Therefore it is best that one insist on the same manufacturer > > or watch to see whether a change in symptoms occurs with a change in > > generics. This does not mean I am against generics. I support their use. > > Just do it with some caution. > > This is correct. However, performing a bioavailibility test (in vivo) for every > batch is far too expensive, so that a more economical (in vitro) Dissolution > Test is substituted. All drug store pharmacists have copies of the USP (United > States Phamacopeia) where that information is available. > Michel