Charles T. Meyer, M.D. wrote: > Thanks for that clarification Michel. I guess the bioavailability test is > done by us titrating our symptoms vs. the drug :-( Actually, the bioavailability test comprises a statistically significant number of 'volunteers' who take the drug as directed and a body fluid sample is taken at regular periods and assayed for the drug or its major metabolite. The available drug content of the samples are then tabulated and validated by statistics to establish an average. One of my questions when I was part of the testing team was that this is test is normally performed on healthy individuals, but might not the age, gender, and health status of the participants of the test affect the bioavailability? In my view, that point had not been answered satisfactorily. Michel