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Rhonda, Everyone's needs for sinemet varies. Just because one person uses a lot less or more than you doesn't mean anything. The important thing is to find the dose that works for you. Since being diagnosed 16 years ago when he was 38, my husband has been trying to find the best dosage. We know that can change from day to day. My husband goes from 1000 mg to 2200 mg, averaging 1600 mg, on any given day. He also takes symmetrel and tasmar, but can't take any of the agonists, he's tried them all. Despite his high dose of sinemet he is still able to work, but it does get harder all the time. Jan cg /Dwayne 54/16 AVERELL ELLIOTT wrote: > Rhonda, > > Your dosage of Sinemet 25/100 5 times per today seems high. I have been > diagnosed 3 years now and only take 25/100 twice per day. Erica