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Dawn, You could try combining a partial tablet of Sinemet 25/100 with a partial tablet of Sinemet CR 25/100 at each dose. For me, this avoids the roller coaster of ON-OFF, somewhat. Eldepryl (selegeline hydrochloride) breaks down to a metam- phetamine. It is something that I can only take 2.5 mg at a time. A COMT-inhibitor like tasmar or comtan may increase your ON-time. Unfortunately, it does cause me to get drowsy. You may need to have your diet evaluated.. And you may have to drink sweetened coffee or tea , or juice (I use O.J.), in case you lack energy due to lowered blood sugar, in addition to citrus sodas, and fruit candies, to give you more energy quickly. May I suggest that you find out if you have low blood pressure from your meds? This can be a source of drowsiness. Most importantly, you REALLY should be evaluated by a movement disorder specialist. It is also helpful if you give us regular updates. Good luck. Ivan i<<dawn>>s On Mon, 18 Oct 1999 17:40:46 -0800 "M. Dawn Legan" <[log in to unmask]> writes: >I'm new here, & have a problem which requires a quick answer(s), as I >see my doctor tomorrow. I was diagnosed in 1993, mainly have the >rigidity-type of PD. I was taking 1-1/2 Sinemet regular l0/100 every >1-1/2 hours for a total of l850 mg/day. I did wonderfully well on >this >for many months, until I got major dyskenesias. Even with these, my >energy & mood were terrific. I suppose I was over-medicated. I have >an >insomnia problem from even before the PD, & some nights while at this >dosage, after the dyskenesias started, didn't sleep at all, because >of >my energy. > >My doctor cut me back to a total of ll00 mg/day to see what would >happen. The dyskenesias are gone, the energy is gone, & some >symptoms >are present. I get sedated very easily, & am concerned that she'll >choose to put me on an agonist or antagonist, or whatever. A year or >so >ago, I tried Requip at a very low, lst week dose, & found it made me >run >around outside or feel excruciatingly trapped inside of the house. >Of >the older supplements, (Mirapex, etc) which have you found to be >energizing, & which sedating? I'm on Klonopin now for anxiety, & >perhaps with that & a major lowering of the Sinemet the Requip might >be >tolerated. > >The older drugs are ergotamine-based. I take Imitrex quite often for >migraines. Nothing prior to that helped. Would I not be able to >take >that with those? > >Again, I've spent so much time over-sedated that that has been my >main >problem in functioning for years. Please tell me what you have found >to >be energizing, or at least, least sedating, in the PD meds. Thanks >for >any info you can provide. > >Dawn ^^^^^^ WARM GREETINGS FROM ^^^^^^^^^^^^ :-) Ivan Suzman 49/39/36 [log in to unmask] :-) Portland, Maine land of lighthouses deg. F :-) ********************************************************************