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Jan is very correct about sinimet dosage. It depends on the person on a given day... I take 50/200CR 3 times a day and 25/100 twice a day in between. On somedays I take 1/2 a 25/100. Stress, exercise, or being overly tired is the reason I need more on some days. I am a tall person 6-4 230 lbs and my large size can accept more so says my Neuro. I also take permax. I think if you work closely with your DR you can find a right dosage. I was very strict with times and dosage when i was first dx'd but the Dr convinced me to try different combos and it worked for me ...Good luck Terry