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hi all after reviewing the pmid abstracts on comt inhibitors i started mulling i hadn't realized that tolcapone crosses the blood brain barrier while entacapone doesn't if the work that this class of med does [saving lovely levodopa from arterial ambush by those vile venous comt conspirators] is done in the bloodstream prior to arrival at the brain station why would either of them have to cross the blood brain barrier? anyway? just a late nite thote about cone pone janet janet paterson 52 now / 41 dx / 37 onset 613 256 8340 po box 171 almonte ontario canada K0A 1A0 a new voice: <http://www.geocities.com/SoHo/Village/6263/> <[log in to unmask]>