Hi janet: Intriguing difference in the mechanism of action, no? I thought I understood the blood-brain barrier business, but now I, too, am confused. Would somebody in the audience please clarify? Carole H. --- janet paterson <[log in to unmask]> wrote: > hi all > > after reviewing the pmid abstracts on comt > inhibitors > i started mulling > > i hadn't realized > that tolcapone crosses the blood brain barrier > while entacapone doesn't > > if the work that this class of med does > [saving lovely levodopa from arterial ambush by > those vile venous comt conspirators] > is done in the bloodstream prior to arrival at the > brain station > why would either of them have to cross the blood > brain barrier? > anyway? > > just a late nite thote about cone pone > > janet > > janet paterson > 52 now / 41 dx / 37 onset > 613 256 8340 po box 171 almonte ontario canada K0A > 1A0 > a new voice: > <http://www.geocities.com/SoHo/Village/6263/> > <[log in to unmask]> > ===== __________________________________________________ Do You Yahoo!? Bid and sell for free at http://auctions.yahoo.com