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At 08:52 1999/10/23 EDT, you wrote: >Janet, >On behalf of those maligned Catachol O Methyl Transferases, >I afta say tat they are just doing their job, Ma'am. Why have >one act within the BBB? In the normal brain, Monoamine oxidase >and COMT are responsible for cleaning up left over dopamine. >However, in the PD brain there is no excess.... aha! so the comt conspirators have nuttin to do just hangin around behind the BBB [blood-brain-barrier] commuter station rumblin for trumble in our poor-pd-put-upon-processors >The idea behind inhibitors as PD therapy is preserving dopamine for >use by the brain not capable of producing adequate supplies of its >own. Dopamine in the synapse is sorta where "the rubber meets the >road. " Avoiding breakdown in the extra BBB area would be helpful >too, but not as helpful... i guess i always got the impression that the 'extra BBB area' [=all the parts of our body-bags which are not inside the brain-bag - ouch] was where the work had to be done and that some outrageous figure like 80% [don't quote me] of levodopa is ambushed by comt conspirators while in transit between the DD [duo-denum] station and the BBB [blood-brain-barrier] station sort of a commuter-bus-hi-jacking in miniature when i talked with my dalk about the possibility and desirability of my starting on tasmar/tolcapone many moons ago i got the impression that the lovely levodopa passenger arrival rates at the BBB station would be not only greater in number but also 'smoother' - there would not be 'holes' left in the bus schedule due to buses disappearing into the comt equivalent of the bermuda triangle but hey i've been wrong before and i'll be wrong again - that's a promise >I predict that entacapone will be the "weaker " of the two drugs. aha! two dusting off our crystal balls are we? and hah! i'll bet those of us [one newfie comes to mind] who suffered from tasmar's side effects will cheer loud and long i also noticed that tolcapone is not taken at the same time as levodopa while entacapone is i wonder what other differences between tolcapone and entacapone could have a bearing on us the guinea pigs? janet who has some cereal correspondence to attend to and apparently is in the perfect frame of mind to tackle it janet paterson 52 now / 41 dx / 37 onset 613 256 8340 po box 171 almonte ontario canada K0A 1A0 a new voice: <http://www.geocities.com/SoHo/Village/6263/> <[log in to unmask]>