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Whoa- Crystal balls, guinea p--s, hi-jackings, and Bermuda Triangles? All this action in my poor depleted AM brain. Time to join you and eat my grits. Carole --- janet paterson <[log in to unmask]> wrote: > At 08:52 1999/10/23 EDT, you wrote: > >Janet, > >On behalf of those maligned Catachol O Methyl > Transferases, > >I afta say tat they are just doing their job, > Ma'am. Why have > >one act within the BBB? In the normal brain, > Monoamine oxidase > >and COMT are responsible for cleaning up left over > dopamine. > >However, in the PD brain there is no excess.... > > aha! > so the comt conspirators have nuttin to do > just hangin around behind the BBB > [blood-brain-barrier] commuter station > rumblin for trumble in our > poor-pd-put-upon-processors > > >The idea behind inhibitors as PD therapy is > preserving dopamine for > >use by the brain not capable of producing adequate > supplies of its > >own. Dopamine in the synapse is sorta where "the > rubber meets the > >road. " Avoiding breakdown in the extra BBB area > would be helpful > >too, but not as helpful... > > i guess > i always got the impression that the 'extra BBB > area' > [=all the parts of our body-bags which are not > inside the brain-bag - ouch] > was where the work had to be done > and > that some outrageous figure like 80% [don't quote > me] > of levodopa is ambushed by comt conspirators while > in transit > between the DD [duo-denum] station and the BBB > [blood-brain-barrier] station > > sort of a commuter-bus-hi-jacking in miniature > > when i talked with my dalk > about the possibility and desirability > of my starting on tasmar/tolcapone many moons ago > i got the impression that the > lovely levodopa passenger arrival rates at the BBB > station > would be not only greater in number but also > 'smoother' - > there would not be 'holes' left in the bus schedule > due to buses disappearing into the comt equivalent > of the > bermuda triangle > > but hey > i've been wrong before > and i'll be wrong again - that's a promise > > >I predict that entacapone will be the "weaker " of > the two drugs. > > aha! > two > dusting off our crystal balls are we? > and > hah! > i'll bet those of us [one newfie comes to mind] > who suffered from tasmar's side effects > will cheer loud and long > > i also noticed that > tolcapone is not taken at the same time as levodopa > while entacapone is > > i wonder what other differences between tolcapone > and entacapone > could have a bearing on us the guinea pigs? > > > janet > who has some cereal correspondence to attend to > and apparently is in the perfect frame of mind to > tackle it > > janet paterson > 52 now / 41 dx / 37 onset > 613 256 8340 po box 171 almonte ontario canada K0A > 1A0 > a new voice: > <http://www.geocities.com/SoHo/Village/6263/> > <[log in to unmask]> > ===== __________________________________________________ Do You Yahoo!? Bid and sell for free at http://auctions.yahoo.com