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At 23:38 1999/10/23 +0100, you wrote: >I wish someone coould make an authoritative statement on the ability of >Tolcapone and/or Entacapone to cross the blood/brain barrier. Janet has heard >that Tolcapone does, and Entacapone doesn't, while I am quite clear that I >was told some time ago (When Tolcapone was originally approved) that >Tolcapone cannot cross the barrier. I remember it well, because I asked my >friendly local neurologist how Tolcapone worked, and he confessed with >some embarrassment that he didn't know, because of the above inability to >cross into the brain. It may also be relevant that Tolcapone was withdrawn >because it caused liver failure (in a small number of people). i.e. in >the body, not the brain. > >-- >Brian Collins <[log in to unmask]> > hi brian i posted 9 abstracts on the subject a few days ago they formed the basis for my comments janet janet paterson 52 now / 41 dx / 37 onset 613 256 8340 po box 171 almonte ontario canada K0A 1A0 a new voice: <http://www.geocities.com/SoHo/Village/6263/> <[log in to unmask]>