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>Date: Wed, 27 Oct 1999 14:07:36 -0700 >Subject: re: Sinemet CR >From: ronald <[log in to unmask]> >To: <[log in to unmask]> > >Charlie, > >reading this: > >http://www.ridgecrest.ca.us/~rfvetter/levodopa.pdf > >or the original report of human subjects usage of CR will, i believe, change >your mind about the breaking into halves of CR tablets. the study included >some dosing with persons taking the same 50/200 tablets some taking both >halves. the efficiency and efficacy and duration werre all better with the >same dosage as two halves. > >i believe that the matrix or binder in the tablets is sort of the majority >of material and the particles of levodopa and carbidopa only gradually are >exposed as the surface recedes. this is consistent with two halves having >the added surface areas of the break. the thickness is the controlling >parameter for duration. if the breaking does not make any dimension smaller >than the thickness, it will last just as long as a whole tablet. > >there is great variability in the peak and when it occurs with CR. the >Madopar slow release configuration is different. > >sincerely, ron >---------- >From: "Charles T. Meyer, M.D." <[log in to unmask]> >Reply-To: "Parkinson's Information Exchange Network" ><[log in to unmask]> >Date: Wed, 27 Oct 1999 10:33:05 -0500 >To: [log in to unmask] >Subject: Re: Please Help! Meds]SInemet with Sinemet CR > >Ivan, > >The timed effect of Sinemet CR is supposedly related to the matrix in which >it is held and released therefore it should not be as efficient as a slow >release preparation if it is broken so Paul is correct. Nonetheless if it >works for you by all means continue to use it. > >Charlie >----- Original Message ----- >From: Ivan M Suzman <[log in to unmask]> >To: <[log in to unmask]> >Sent: Tuesday, October 26, 1999 9:31 AM >Subject: Re: Please Help! Meds]SInemet with Sinemet CR > > >> hI Ron, and the FAHRS, >> >> I use partial CR's , and partial 25/100's. Usually 1/2 of a >> Sinemet25/100, crushed in mouth, >> then OJ or citrus-based soda, then, about 2/3 CR immediately, and so, the >> combination works for me. >> >> I get longer on-times, and yet, what works for me may not work for you... >> I also use Eldepryl and Tasmar. >> >> Ivan :-) >> >> On Fri, 22 Oct 1999 08:36:12 -0700 "Ronald F. Vetter" >> <[log in to unmask]> writes: >> >P&B Fahr <[log in to unmask]> wrote: >> > >> >Ivan, >> >Isn't using 1/2 a Sinemet and 1/2 a CR equal to taking 1 >> >Sinemet since breaking a Sinemet CR destroys its >> >timed-release feature and it effectively becomes plain >> >Sinemet? >> > >> >the statement that breaking CR Sinemet of either size into halves >> >changes the slow dissolving is absolutely NOT true. >> > >> >read or download >> >http://www.ridgecrest.ca.us/~rfvetter/levodopa.pdf >> > >> > >> >Ron Vetter 1936, '84 PD dz >> >mailto:[log in to unmask] >> >http://www.ridgecrest.ca.us/~rfvetter >> >> ^^^^^^ WARM GREETINGS FROM ^^^^^^^^^^^^ :-) >> Ivan Suzman 49/39/36 [log in to unmask] :-) >> Portland, Maine land of lighthouses deg. F :-) >> ******************************************************************** > > janet paterson 52 now / 41 dx / 37 onset 613 256 8340 po box 171 almonte ontario canada K0A 1A0 a new voice: <http://www.geocities.com/SoHo/Village/6263/> <[log in to unmask]>