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On Sat, 23 Oct 1999 03:56:26 -0400 janet paterson <[log in to unmask]> writes: >hi all > >after reviewing the pmid abstracts on comt inhibitors >i started mulling > >i hadn't realized >that tolcapone crosses the blood brain barrier >while entacapone doesn't > >if the work that this class of med does >[saving lovely levodopa from arterial ambush by those vile venous comt >conspirators] >is done in the bloodstream prior to arrival at the brain station >why would either of them have to cross the blood brain barrier? >anyway? Catechol O'methyl Transferase - or COMT - is ALSO inside the brain, as far as I know. SO that is why I am taking tolcapone (Tasmar)- since I want both sides of the "blood-brain barrier" to be cleared of COMT. My question is: is entacapone as effective, less effective, or more effective than tolcapone?!! > >just a late nite thote about cone pone > >janet > >janet paterson >52 now / 41 dx / 37 onset >613 256 8340 po box 171 almonte ontario canada K0A 1A0 >a new voice: <http://www.geocities.com/SoHo/Village/6263/> ><[log in to unmask]> ^^^^^^ WARM GREETINGS FROM ^^^^^^^^^^^^ :-) Ivan Suzman 49/39/36 [log in to unmask] :-) Portland, Maine land of lighthouses pouring rain, 52 deg. F :-) ********************************************************************