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Hi, Of course, I have no idea what your needs are, or how/when you're taking 25/100, 12/day, but--- Yes, that sounds like too much Sinemet, and too little Requip. Do you really need Sinemet that frequently to stay functional and/or rescue you from the symptons? Can you increase Requip, and add a COMT inhibitor to maximize and perhaps lower the Sinemet? It seems from the way you worded it, that you don't feel like the amount/frequency of Sinemet is necessary. Are you taking the Sinemet on an empty stomach; have you tried CR? Good luck. Charlotte ---------------------------- "Gregory J. Sterling" wrote: > Please tell me what your opinion is on taking 12-sinemet 25/100/day and 6 mg Requip/day. > > Is that a lot of sinemet? When I read that people are taking 3 or 4 tablets a day it makes me wonder. > > Thanks. -- Charlotte Mancuso *************************************************** For advocacy, medical, and other PD-related material, go to: http://www.onelist.com/subscribe/CurePD-NorCal