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Michel, Requip like the other agonists can cause psychosis just as can l-dopa. Schizophrenia appears to be a diaeae of DOPAMINE EXCESS(much oversimplified) while PD of course is a disease of dopamine deficiency. While usually Requip does not cause psychosis, in a person who has had serious episodes of psychosis in the past and is elderly and physically compromised, I would be very cautious about the increase of Requip or other agonist . ----- Original Message ----- From: Michel Margosis +ADw-michelmarg+AEA-EROLS.COM+AD4- To: +ADw-PARKINSN+AEA-listserv.utoronto.ca+AD4- Sent: Friday, October 29, 1999 9:52 PM Subject: Re: Opinion +AD4- Charles T. Meyer, M.D. wrote: +AD4- +AD4- +AD4- I wrote to GReg +ACI-If you can take it+ACI- Psychosis is a side effect of requip +AD4- +AD4- and other agonists. You have to balance the benefits against the side +AD4- +AD4- effects and with Peter and his history and age I would be very careful. +AD4- +AD4- Our neuro was considering Requip for Barbara as replacement for Permax. She had +AD4- been briefly on Tasmar and did well with it, but because of history of liver +AD4- problems, was taken off and back on Permax. +AD4- I think the cost of further diminishing cognitive functions may be too much of a +AD4- price to pay yet for unknown benefits. Barbara hallucinates during the day and +AD4- occasionally screams and kicks at night, and is terribly apprehensive of +AD4- dementia. She is also on Celexa (antidepressant), Aricept (anti dementia), +AD4- Seroquel (for nightmares). +AD4- If psychosis is a fairly common side effect of Requip, it does not appear to me +AD4- to have sufficient 'risk/benefit' value as an agonist. +AD4- Michel