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Ron and (I think Janet also responded). And Ivan. In the data presented on the website I could find no credible data which counters the assertion that I have made (as has the manufacturer). The matrix will dissolve related to the surface area of the pill that is exposed . That does not say that there isn't an advantage to doing it because by delaying the timed release at all you naturally prolong the higher blood level. Chewing the pill or allowing it to dissolve totally before it is ingested would almost totally cancel out the delay effect but one can get an immediate effect and then delay some of the effect by breaking the tablets. I suggest that you do what works for you for whatever reason. ----- Original Message ----- From: Ronald F. Vetter <[log in to unmask]> To: <[log in to unmask]> Sent: Friday, October 22, 1999 10:36 AM Subject: Re: Please Help! Meds] > P&B Fahr <[log in to unmask]> wrote: > > Ivan, > Isn't using 1/2 a Sinemet and 1/2 a CR equal to taking 1 > Sinemet since breaking a Sinemet CR destroys its > timed-release feature and it effectively becomes plain > Sinemet? > > the statement that breaking CR Sinemet of either size into halves > changes the slow dissolving is absolutely NOT true. > > read or download > http://www.ridgecrest.ca.us/~rfvetter/levodopa.pdf > > > Ron Vetter 1936, '84 PD dz > mailto:[log in to unmask] > http://www.ridgecrest.ca.us/~rfvetter