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Hi Joe and all from Erika Thanks for more great CSR's, they often spark some thought. CURRENT SCIENCE REVIEWS By Joe Bruman November 1999 P. 1 of 2 >Becker G et al; Neur 1995;45:182-184: >One might think the brain's bony case prevents imaging with the >simple technique of ultrasound, but it turns out that acoustic >windows make it possible. They compared PD patients with healthy >controls, and found the substantia nigra in the PD group to be >distinctly more reflective than normal. Does anyone have any idea "what" is the cause of this extra reflectiveness? Would there have to be a "substance" present in the substantia nigra that causes this? i have always thought of the reduction of dopamine producing cells as leaving spare room (for want of a better expression). This I thought would leave the PD groups' Substantia Nigra as "less" reflective. I'm not sure how an ultrasound works (though I did have one whilst pregnant) Would one of the doctors on the list be willing to explain "what" we see, that causes the image in ultrasounds? With thanks from curious-Erika.