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Marty, and other Pain-in-a-joint(s) Miripexer PWPs... When Miripex first came out - when was that... maybe 2 years ago or so - I started taking it, starting with a minimal dosage daily, and slowly taking less Sinemet (the only PD drug I take). Within 3 days, I began to have TERRIBLE pain in both hip joints. I mean MAJOR PAIN! As I usually do when a new symptom - ANY symptom - I sat myself down and thought about my diet in that 3 day period, any over-the-counter drugs I might have taken, etc.., and also took into account that I 17 years ago had been medically diagnosed as having rheumatoid arthritis (my sister has the worst case of that I've ever seen except for did our fraternal grandmother). My initial attack of RA went into remission when I was treated with 800 mg. of Motrin taken twice daily for six months After taking mental stock of my imediate history, the ONLY thing I could find in my life that was had been changed in that time period was Miropex, which I IMMEDIATELY ceased taking. The pain took about a month to get down to a "bearable level," and then another month to completly go away. At that time I decided to try the Miripex once again, only to find myself once again in severe pain in both hips. it took less than 24 hours to kick up this time, and SIX months to go away. I haven't ahd any further hip or joint pain since I stopped takimg Miripex. You couldn't PAY me enough to take another Miripex now, and I ALSO give any new PD drug at LEAST 6 to 8 months in the commercial (as opposed to the medical testing lifespan of a new drug) marketplace before I even consider taking it, and that rule has stood me in good stead, 'cause I've concluded that there is a LOT that goes on behind the backs of the general public by the medical research companies, rushing to get a new drug to run the FDA gauntlet in order to get a new drug to turn into a money making investment. If it was ME in your shoes, I'd stop the Miripex. Remember if you decide to do that to ramp down slowly rather than to go cold turkey. Please keep us posted about "Marty's adventure in Miripexland... Barb Mallut [log in to unmask] -----Original Message----- From: Marty Rose <[log in to unmask]> To: [log in to unmask] <[log in to unmask]> Date: Wednesday, November 10, 1999 7:15 AM Subject: Re: Mirapex side effects >I am very curious about all the banter about knee pain and Mirapex. I have >become almost incapacitated by knee pain and stiffness in other joints. >Looking back now I can honestly say that I think it started getting bad when >I started Mirapex. I may be just grasping a straws here,but enough people >have jumped on the band wagon to make me stop and think. I take 4mg/day >presently along with Amantadine and SInemet25/100 6-8per day. I am tempted >to ask my neuro to switch agonists. Any opinions? > >Marty 59/50/9