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Hi Brian, You wrote : > As far as my case goes, T see no involvement of levodopa. My usage > of it has been stable for years, at 800 mg/day (I also take Permax, and > this I increase steadily by half a tablet every 6 months to counter my > deterioration. Recently I went up from 5 1/2 to 6 x 1mg Permax per day > quite high, but I think that if anything, it is probably the on-coming > point where vitually all the natural dopaminergic cells are dead and I > must rely on the tablets that has started the distonia. > If all the natural dopaminergetic cells are dead how could be explained that after a surgery such as a Palidoctomy may eliminate , or reduce , the need of levodopa and do the same with many of the symptoms of PD ?? Best , +----| Joao Paulo de Carvalho |------ + | [log in to unmask] | +--------| Salvador-Bahia-Brazil |------+