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In re:Mirapex side effects in my own history with PD meds, I took Mirapex(1mg 3xs daily) w/segeline for about 6-7 months. I had some drowsiness to the point I was afraid to drive alone at highway speeds and some dizziness that my mds said could be either the agonist, the mao inhibitor(segeline) or pd itself. I wanted to go back on SinemetCR but lst tried PERMAX with the unfortunate side effect of extreme stomach acidity. Finally, I called and talked w/the nurse at my mds office and told her my pd symptoms were worse, my stomach was upset w/heartburn after all kinds of food and could I PLEASE reintroduce SINEMETCR until my upcoming office visit in 2 weeks. My mds was paged, answered the page and said to slowly reintroduce SINEMETCR and decrease PERMAX. Have since stopped PERMAX and taking only SINEMETCR am feeling MUCH BETTER and pd symptoms of slowness, rigidity and unbalance are now controlled in a way that allows me to enjoy work, family life, and I'm enjoying the "honeymoon" that levodopa/cardopa provides. I'd hoped that agonist only would be effective for my pd symptoms, but the side effects were worse than the symptom relief. You may find that Mirapex works; it does for some pwp. I'd suggest being careful with any med change to S L O W L Y titrate up and realize that a theraputic dose of test trials may not be the doze that is effective for you. I often use LESS than recommended dose of over the counter drugs and have found through trial/error that pd doses for me are sometimes less than recommended by drug trials of drug manufacturers. Hope you figure out what is best. Patience and keeping a daily diary of when & amt of meds taken, foods eaten, stress of the day and how your body/mind feel when taking the new drugs can help you tell your dr/nurse how the drug makes you feel. It is often a good indication of what is causing a particular problem. Jeanette Fuhr 49/47/44? ---------- From: Tina <[log in to unmask]> To: [log in to unmask] Subject: Mirapex side effects Date: Monday, November 08, 1999 8:21 PM I am looking for any info on Mirapex side effects....The only side effect I can find is about falling asleep. I am having bad joint pain in my knees. Just started saturday, and I started my full dose of Mirapex friday (1.5mg)day. I am also on Amantadine (generic for Symmetrel). Still having tremors and balance problems, so far Mirapex really hasnt helped me. I already have a call into my doctor, waiting for return call. Just trying to get more info before I see the doctor. He will not put me on sinemet because he says I am too young. He said the longer you take it, the worse side effects you get down the road. He said he only gives it to his older patients. My symptoms are tremor in right hand, and head...balance problems, fallen 5 times in past 2 weeks, joint pain in knees, right leg dragging and freezing (which has caused most of falls), depression, fatigue, and trouble walking any distance. I am only 31 yrs old. Any info would be greatly appreciated. My doctor is really good, he and his team of doctors are third in the nation in pallidomy surgeries. I really am just looking for ideas or thoughts to bring up to my doctor when I go see him. Thanks, and sorry for being so winded. Tina-----Fairfield, Ohio