In a message dated 11/9/99 2:05:42 AM Central Standard Time, [log in to unmask] writes: << good sinemet management is the key to long useability, IMHO 11 years later i now have "on" and "off" times when my symptoms are under control and when they are not, so sinemet doseage and timing becomes a fine art and require close attention and patience but that's a small price to pay for the benefits [again, in my humble opinion] >> AIMHO (and in my...), too Regards, WHH