Witholding Sinemet in early PD is stupid, and it doesn't
work. Of course
proving that it doesn't work is virtually impossible because
you can't go
back and try again. It has to be done by logic, and I have
done that - not
here,
I've just indulged myself by letting off some steam in this
e-mail,...
Please note: I do not follow one-size-fits-all therapy for PD suffers at any
age. Having said that, I feel I must answer this outrageous example in dogma:
Without speculating on what your motives are for passing on your opinions as the
only logical way to think, I must say I find it truly irresponsible. I welcome
opinions, but not opinion given as dogma.
Where is your scholarly proof? All I hear is your personal, anecdotal opinion.
The fact that you have written a lot about your opinion doesn't make it fact. I
find that a zealot's belief and reasoning and/or logic to be oxymorons. If this
sounds harsh, it was meant to be. Now I'm being candid when I say that I cannot
abide by zealots of any kind.
Please, at least qualify what you say about PD protocols as your opinion and NOT
GOSPEL! You do not have the qualifications to pass on totally unqualified,
unquantified, DOGMA as the truth, the whole truth, and nothing but the truth. No
matter how long and hard to have thought about it, practiced it, and PREACHED it,
and no matter how many believers or disciples you have following your regimen for
PD, and your beliefs about treating PD, it is still YOUR OPINION, and nothing
more. It's not only unreasonable, it's irresponsible, and, perhaps, even
dangerous to do otherwise.
Charlotte Mancuso
--------------------------------
Brian Collins wrote:
> I am in full agreement with Janet on the subject of delaying Sinemet. It is
> one of those situations where someone happens to start a trend (with nothing
> to support it, and all the other lemmings surge into action. And 40 million
> lemmings can't be wrong, can they?
>
> In this example of ludicrous logic, I have managed to put together what I
> think is the reasoning (or should that be unreasoning) which led to the
> witholding of levodopa fashion:
>
> 1) It is well known that you can't achieve a satisfactory control of PD
> symptoms with Sinemet beyond about 7 or 8 years, due to the dyskinesias and
> 'motor fluctuations'. I haven't heard a decent definition of Motor
> Fluctuations, but never mind, it must be a really bad place to go.
> (By the way, I controlled my symptoms quite acceptably for 14 years, by
> a rational and careful application of Sinemet, and have written quite a
> lot about the subject, but I doubt if any professionals have understood my
> arguments.
>
> 2) Here it comes, the giant leap for mankind: The Sinemet would behave
> much better at the 7 to 8 year point, if we avoided using it at all in the
> early days of PD. How? Why? Where is the reasoning? There is none because
> the whole proposition is ludicrous. Have they forgotten that we are dealing
> with PD here? I doubt that anyone in the world of PD has ever made the
> slightest impression on the rate of deterioration of anyone's PD symptoms
> (Of course, there is a range of deterioration rates, but each person's
> rate is his own, and there is no changing it.
>
> That rate of deterioration has nothing to do with Sinemet:it is loss of brain
> cells which is the cause. By the way, I forgot to mention that I took Sinemet
> alone for 14 yrs, And I took Sinemet for all but the first year of PD, AND
> I still take Sinemet 800 mg/day of levodopa at 21 years since diagnosis!!
>
> Witholding Sinemet in early PD is stupid, and it doesn't work. Of course
> proving that it doesn't work is virtually impossible because you can't go
> back and try again. It has to be done by logic, and I have done that - not
> here, I've just indulged myself by letting off some steam in this e-mail,
> but you can if you wish follow my more rational writings in the following
> web site
>
> http://james.parkinsons.org.uk/brian.htm
>
> Happy reading,
> Regards
>
> --
> Brian Collins <[log in to unmask]>
--
Charlotte Mancuso
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