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I don't think so; but what do I know? I haven't had it myself, and I'm not even a medical professional, but I see reports of it from a few list members, that make me wonder. As I said before, the Merck Manual doesn't mention it, although it does impute certain ANTI-dopamine drugs, and it has plenty to say about the various forms of dyskinesia and their cause. Likewise, the long paragraphs in the PDR Sinemet description covering Warnings, Precautions, and Adverse Reactions (note the descending order of importance) contain no mention of dystonia caused by Sinemet, except when it is taken together with a tricyclic antidepressant, a class of drugs well-known to counter the action of levodopa. So how explain reports from a minority of listmembers, contradicting the overwhelming majority experience and conventional wisdom? I suspect the problem is semantic. It's hard to define exclusively the difference between dyskinesia and dystonia, and even harder to interpret what each different patient thinks he feels. I've mentioned elsewhere the possible confusion of very mild peak-dose dyskinesia with resting tremor, and since tremor, dyskinesia, and dystonia all involve the contraction of muscles, perhaps the latter two can possibly be confused sometimes. In any case, I've not yet heard of dystonia like that described by Marty related positively to levodopa. The question might be resolved if he follows his neuro's advice to avoid Sinemet (and other dopaminergic drugs), but IMHO, since Marty certainly has PD, that doesn't sound like a very good idea. Cheers, Joe -- J. R. Bruman (818) 789-3694 3527 Cody Road Sherman Oaks, CA 91403-5013