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In a message dated 11/10/99 9:14:29 AM Central Standard Time, [log in to unmask] writes: << I take 4mg/day presently along with Amantadine and SInemet25/100 6-8per day. I am tempted to ask my neuro to switch agonists. Any opinions? >> Marty, I had a similar experience. While the stuff worked well on PD symptoms, my ankles started swelling. I tried switching agonists to Requip. That particular trial ended miserably (Off all morning, dyskinetic all afternoon and evening). When I restarted Mirapex I increased the dose very slowly and stopped well short of the previous dose. I now take ¼ of a 1 mg tablet with each of six doses. My ankles have a hint of swelling. The situation has been stable for about a year now. Regards, WHH 56/38/37