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George FWIW(for what it's worth) mirapex has been very beneficial to me. i also take selegeline and amantadine. mirapex permitted me to stop taking sinemet CR. i believe that the most important thing you can do is to insure that your neurologist has a great deal of experience in treating PD. there are many neurologists who do not have the necessary experience in PD. above all, do not be afraid to ask questions. make sure that your neurologist is willing to work with you closely on your treatment. It will take time for both of you to learn to deal with PD. unfortunately it does not come with instructions. if you have any questions, e-mail me at [log in to unmask] murph 57/9 On Sat, 20 Nov 1999 14:00:09 -0000 George Hough <[log in to unmask]> writes: > I am new to the list and may have missed the postings pertaining to > my > question. I have read some 200 messages so far and none refer to > the > medication my husband has been given. It is called Mirapex. Anyone > out > there know about it. He has also been given another product meant > to > enhance the Mirapex because his neurologist was not happy with the > lack of > progress. We are new to this...he was diagnosed about 6 weeks ago. > We are > still very frightened about it all. He is 53 years old and planned > to > retire from teaching in a couple of years. Now, God only knows! > > yvonne > -----Original Message----- > From: Brian Collins <[log in to unmask]> > To: [log in to unmask] <[log in to unmask]> > Date: Saturday, November 20, 1999 5:13 PM > Subject: Dyston ia - Further thoughts > > > >Now that I have had time to do some investigation into the strange > >phenomenon called Dystonia, and have now (for the time being), got > >it under control. Some of you may find the following points of use. > > > >1) It is important to emphasize the difference between straight > forward > > Cramp and Dystonia; they are VERY different. Cramp (in my case) > occurs > > because I have inadvertantly affected the flow of blood to or > from my > > leg(s) by lying with one leg on top of the other -as an example. > A semi- > > conscious stretch then rapidly develops into a painfully-knotted > muscle > > which can best be sorted out by standing up and walking a few > paces. > > > >2) Dystonia, seems to attack when the conditions are similar to > those for > > cramp, but can strike at other times as well. > > > >3) Early postings on this subject referred to 'Peak Dose > Dystonia': > > While such a phenomenon may exist, it would never be > encountered during > > my testing, because all settings are biased towards finding the > minimum > > effective flow, rather than the maximum permissible flow rate. > > > >4) The key point which makes dystonia different to cramp is that > it > > involves groups of muscles of such outlandish combination that > their > > selection could only be accomplished in the brain. I thus > decided to > > look at the levodopa levels existing in the brain in the early > morning > > hours, where the Dystonia was occuring. It was immediately > obvious > > that just before waking at about 7;00am my dopamine levels > would be > > sinking to just about zero. > > > >5) I tried adding a tablet (50mg) of Madopar Dispersible when I > woke up > > at around 4:00 am (One of several times at which I float up to > the > > surface before going back to sleep.) > > > > The outcome from adding the extra tablet has been an immediate > halt > > to the incidents of Dystonia. For the time being, I seem to > have > > a cure for my dystonia. > > > >I would like to hear from anyone who tries the 1-shot booster > tablet > method, > >to see how generally the principle applies. > > > >Regards, > >-- > >Brian Collins <[log in to unmask]> > >