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Gil Lieberman wrote: > Would someone please explain the difference between Entacpone(Comtan) > and Tolcapone (Tasmar)? > As I understand it, both are ComT inhibitors.But what are the > differences,and advantages and disadvantages of each? > For what stages of PD are these drugs recommended? Tasmar (Tolcapone) was found to be toxic and sevral times caused fatalities by damaging the liver. At this time, those still using it have to be tested every two weeks. Comtan (Entacapone) was recently approved by the FDA for essentially the same therapy, and so far has been found to be efficacious without serious adverse effects. Michel