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In a message dated 11/17/1999 10:37:58 PM Pacific Standard Time, [log in to unmask] writes: y Mom has hallucinations brought on by Sinemet. We learned at a support group meeting that the hallucinations come after seven or eight years on Sinemet. She is now on Sinemet CR--minimum dose possible--and Resperidal for the hallucinations and confusion. The Resperidal worked for a while, but doesn't seem to be helping as much now. Eleanor, There's a whole class of relatively new anti-psychotic medications, all of which affect different pipette differently, and most of which are safe for PD. The most effective of these is clozaril (or clozapine), which requires careful monitoring with weekly blood tests for potentially serious side effects but if you the monitoring protocol faithfully, these are highly unlikely to occur. My point is that unlike 5-10 years ago, there are now several anti-psychotic drugs which can safely and effectively treat psychotic symptoms in PD patients. I suggest that you ask your mother's neuro if he/she has considered other anti-psychotic agents besides respiradol for your mother, and if he/she has, why were they ruled out. If you can't get reasonable answers to these Q's, I suggest that you find another neuro. Good luck. Marty Polonsky, Ph.D. Clinical Psychologist