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In a message dated 11/20/99 10:13:13 AM Mountain Standard Time, [log in to unmask] writes: << I would like to hear from anyone who tries the 1-shot booster tablet method, to see how generally the principle applies. >> Hi Brian. I, too, have been experimenting with a 'shot' (sinemet)at 4 a.m. or even earlier whenever I first wake up. So far (3 nights in a row) there has been very little relief. My dystonia has developed in the shoulder/neck, left side. Began on Tuesday the l6th at 4:30p.m. and continues at this time. It abates for a few hours to a tolerable ache, then builds to a crescendo. This building up is another cycle I'm tracking on a chart to pin down exactly where I am in my dosing. Coincidentally, I am in the process of switching over from SinemetCR 25/l00 to regular sinemet 25/l00 , a plan which was expected to eliminate the mid-afternoon dyskinesia. That expectation has been realized. But also, to complicate the diagnosis further, I didn't get the regular sinemet from the drug store until Wednesday, the l7th, so I believe that is significant. Boy, one should be a rocket scientist to sort out all this stuff. In the meantime the ache/pain goes on and on. I've been trying to get a TENS unit, with many obstacles such as Medicare and Secondary and prescribing doctor, etc., etc., and feel next week may turn up some relief. I hate to ask my doc for a muscle relaxant until I have tried this TENS. Have you ever used one? Do you have any suggestions for me, Brian? I am so INTO this problem that I can't think straight. Thanks, Clare Wiilson