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Carole Hercun wrote: > > Dear Joe: Tricyclics countering the action of levodopa? How > come I didn't know this? More important, how come my neuro > didn't know this? Any refences will be appreciated. Thanks, you're right (again!). I don't know how memory can play such tricks. In fact, tricyclic antidepressants such as Elavil or Toframil are recommended (Duvoisin, 4th ed., p.72) as possibly working even better when combined with levodopa (Sinemet) therapy in depressed PD patients. I still think, BTW, that mood swings due to the intermittent nature of levodopa dosage are too often mistaken for clinical depression; but that's a completely different topic. Returning to dystonia, even the rare exception from the Precautions paragraph is wrong, in my haste I misread "dyskinesia" as "dystonia". Anyway, the substance of my posting remains: The particular kind of dystonia reported by Marty (whom, incidentally, I have observed in person) has not to my knowledge been associated with Sinemet, although something like it may occur in the absence of PD. Cheers, Joe -- J. R. Bruman (818) 789-3694 3527 Cody Road Sherman Oaks, CA 91403-5013