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Teresa, That would be an excellent question for "Ask the Doctor." Why don't you go to NPF's website, and post your question to Dr. Lieberman? http://www.parkinson.org/drindex.htm Best Kathrynne "Teresa V. Bohuszewicz" wrote: > Comtan is suppose to be taken with Sinemet at the same time. I assume that > most people would take their Sinemet tablet along with their Comtan tablet. > (I do understand how Comtan works as a COMT inhibitor.) Because Mama takes > her Sinemet not in pill-form but already dissolved in water, wouldn't it > make sense to take the Comtan tablet 10 or 15 minutes prior to taking the > dissolved Sinemet? This would give the Comtan time to dissolve in the > digestive system and reach the COMT before the Sinemet is interfered by the > COMT. If Mama takes her dissolved Sinemet concurrently with her Comtan > tablet, wouldn't the Sinemet reach the bloodstream before the Comtan? > > Teresa, Daughter of Mama (57/43/38) -- Kathrynne Holden, MS, RD Medical nutrition therapy for Parkinson's disease Author: "Eat well, stay well with Parkinson's disease" "Parkinson's disease: assessing and managing unique nutrition needs;" "Risk for malnutrition and bone fracture in Parkinson'sdisease," J Nutr Elderly. V18:3;1999. http://www.nutritionucanlivewith.com/