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Teresa, I've been taking Comtan since June 1994 and have had no problem with digestion of Comtan. I have not taken Sinemet in liquid form. 1. Comtan tastes far worse than Sinemet to me. Comtan tablets dissolve fairly rapidly, but not so fast as the standard Sinemet or the Teva generic Sinemet equivalent.. 2. Comtan tablets are relatively large, and I have found them hard to swallow when I am "off." [Off is when I have not had my Sinemet for a few hours or overnight.] Comtan tablets give me a burning-choking feeling when they get stuck in the throat. You did not say why your mother was using liquid Sinemet rather than using the pills as is. If she has trouble swallowing Sinemet, Comtan will be far worse. She may find the Comtan easier to handle after she has had some positive effect from her Sinemet. Will Johnnston A.P.D.A. DelMarVA Chapter Pres. 4049 Oakland School Road Salisbury MD 21804 USA 410-543-0110 ---------- From: Teresa V. Bohuszewicz <[log in to unmask]> To: [log in to unmask] Subject: LIST: Digestion question about Comtan Date: Wednesday, November 24, 1999 9:46 PM Comtan is suppose to be taken with Sinemet at the same time. I assume that most people would take their Sinemet tablet along with their Comtan tablet. (I do understand how Comtan works as a COMT inhibitor.) Because Mama takes her Sinemet not in pill-form but already dissolved in water, wouldn't it make sense to take the Comtan tablet 10 or 15 minutes prior to taking the dissolved Sinemet? This would give the Comtan time to dissolve in the digestive system and reach the COMT before the Sinemet is interfered by the COMT. If Mama takes her dissolved Sinemet concurrently with her Comtan tablet, wouldn't the Sinemet reach the bloodstream before the Comtan? Teresa, Daughter of Mama (57/43/38)