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Morning dear listmembers. I have tried Tasmar which I was very ill from twice, This summer I started Entacopone (COMTESS) but after only one month and it seems to help me, unfortunately the sideeffect was very bad, I had diarrhoe 6-8 times a day . and also had to vomit every day. ofcourse my neuro asked me to stop. I have been talking with other pwp in our Parkinson club, and it seems until now I+AGA-m one of the few who had sideeffect from Comtess. Of course I was sorry about this, because it helped me. Instead of I started with PRAMIPEXOL 6 weeks ago very slowly because it+AGA-s hard for me to tolerate all that stuff, and until now it+AGA-s the best happened to me, more energy and some point of the day I+AGA-m walking without my sticks. Michel, hugs to Barb and you, hope she is doing better, and also nice to hear about your new apatment :-)) love Sonia NEVER GIVE UP ----- Original Message ----- From: Michel Margosis +ADw-michelmarg+AEA-EROLS.COM+AD4- To: +ADw-PARKINSN+AEA-LISTSERV.UTORONTO.CA+AD4-Sent: 22. november 1999 04:47 Subject: Re: Entacapone vs Tolcapone +AD4- Gil Lieberman wrote: +AD4- +AD4- +AD4- Would someone please explain the difference between Entacpone(Comtan) +AD4- +AD4- and Tolcapone (Tasmar)? +AD4- +AD4- As I understand it, both are ComT inhibitors.But what are the +AD4- +AD4- differences,and advantages and disadvantages of each? +AD4- +AD4- For what stages of PD are these drugs recommended? +AD4- +AD4- Tasmar (Tolcapone) was found to be toxic and sevral times caused +AD4- fatalities by damaging the liver. At this time, those still using it have +AD4- to be tested every two weeks. +AD4- Comtan (Entacapone) was recently approved by the FDA for essentially the +AD4- same therapy, and so far has been found to be efficacious without serious +AD4- adverse effects. +AD4- +AD4- Michel