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First to bring anyone who cares up to date: As a result of readings on the list, I self prescribed 100 mg of CO Q10. Then someone posted the URL of the NOAH site and there I saw that studies were being conducted at 10 sites in the country (stage three trials) to test the neuroprotective properties of the supplement. Think of it. Not something to ease the symptoms but rather something to slow (maybe halt?) the progress of the disease. Three different dosages/day were being double blind tested for 16 months: 300, 600 and 1200 mg. I immediately called my neuro and asked him if he had any objection if I upped from my 100 mg self prescribed to 300 mg (there's a limit to the decisions I, an engineer will take on my own medically). He said fine. I told most of this to the list a while ago and asked if anyone knew of an inexpensive source of the supplement. Two members both replied with the same source, Lifewise Naturals, 1-800-643-9558 (honest, I'm not shilling for them), where they have three levels of pricing depending on quantity, but at any level, almost 1/2 of the cost in my local drugstore. I bought 12 bottles of 60 each 100 mg capsules, the best price level they have. So now I'm taking 300 mg a day and it occurs to me that while I wait for the GM1 Ganglioside people to make up their minds if they will accept me into their study (another neuroprotective study), I might as well see if I can get accepted into one of the CO Q10 studies so I spoke with the people at the study sites in both Albany, NY and Philadelphia, PA, each about equidistant from me. As it happens I do not qualify for the study because they want newly diagnosed pwp who take no medication, a difficult find since the study runs for 16 months and one needs medication during that period, they would of course be advised to start but would then have to drop out of the study. Had a longish conversation with the RN Ph.D. at the Phila site and we agreed that I would be an unofficial study member and fill her in from time to time on how I was doing. This last after a discussion of possible downsides of increasing to 1200 mg/day, of which she said none had been reported by any sit e during the current trials and as far as she knew, none had been reported during the phase 1 &2 trials (although one of those trials might have been with people with Huntington's Disease). She told me they do a blood test every three or four months checking the liver function in specific. All in all, the conversation was much freer than I would have anticipated and I presume that speaks to her own self-confidence. So, I went to see my neuro this afternoon (previously scheduled appointment to discuss the progress of my attempt to get off Sinemet by substituting Requip - but that could be the subject of another post if anyone cares), and told him of my conversation with Ms. Reichwein (that was the RN Ph.D.) and suggested that I wanted to try 1200 mg. He agreed, although he suggested I titrate up 100 mg/week until I get there and he gave me an order for a blood test on a month. So ends another long tale of learn from the list to be proactive - at least for now! Regards, Paul H. Lauer (who despite everything, misses Janet and her posts very much - please come back if you're up to it)